おすすめの製品
由来生物
mouse
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
P3D1, monoclonal
化学種の反応性
mouse, human
化学種の反応性（ホモロジーによる予測）
rat
テクニック
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
アイソタイプ
IgG2a
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ENG(2022)
mouse ... Eng(13805)
rat ... Eng(497010)
詳細
Endoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
特異性
Reacts with human endoglin.
免疫原
Human resting umbilical vein endothelial cells.
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
成長因子及び受容体
成長因子及び受容体
Anti-Endoglin Antibody, clone P3D1 is an antibody against Endoglin for use in WB, IH, IC, IP, FC, ELISA.
Immunohistochemistry: For use on acetone or paraformaldehyde fixed tissue.
ELISA: A previous lot of this antibody was used in ELISA.
Immunoprecipitation: A previous lot of this antibody was used in IP.
Immunocytochemistry: A previous lot of this antibody was used in IC.
Flow Cytometry: A previous lot of this antibody was used in FC.
Optimal working dilutions must be determined by the end user.
ELISA: A previous lot of this antibody was used in ELISA.
Immunoprecipitation: A previous lot of this antibody was used in IP.
Immunocytochemistry: A previous lot of this antibody was used in IC.
Flow Cytometry: A previous lot of this antibody was used in FC.
Optimal working dilutions must be determined by the end user.
品質
Routinely evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates.
ターゲットの説明
~71 kDa
関連事項
Replaces: MAB2152
物理的形状
Purified
Format: Purified
Purified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6
保管および安定性
Stable at 2-8°C for up to 1 year from date of receipt.
アナリシスノート
Control
Jurkat cell lysate
Jurkat cell lysate
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
05-1424:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Nicole M Valenzuela et al.
Journal of immunology (Baltimore, Md. : 1950), 190(12), 6635-6650 (2013-05-22)
Ab-mediated rejection (AMR) of solid organ transplants is characterized by intragraft macrophages. It is incompletely understood how donor-specific Ab binding to graft endothelium promotes monocyte adhesion, and what, if any, contribution is made by the Fc region of the Ab.
Snail1 controls TGF-? responsiveness and differentiation of mesenchymal stem cells.
Batlle, R, et al.
Oncogene (2012)
Lulwah Aldabbous et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(10), 2078-2087 (2016-07-30)
Inflammation and dysregulated angiogenesis are features of endothelial dysfunction in pulmonary hypertension. Neutrophil extracellular traps (NETs), produced by dying neutrophils, contribute to pathogenesis of numerous vascular disorders but their role in pulmonary hypertension has not been studied. We sought evidence
Takuya Tokunaga et al.
The American journal of sports medicine, 43(10), 2411-2422 (2015-08-28)
Fibroblast growth factor (FGF)-2 has the potential to enhance tendon-to-bone healing after rotator cuff (RC) injury. FGF-2 stimulates tenogenic differentiation of progenitors to improve the biomechanical strength and histological appearance of repaired RCs in rats. Controlled laboratory study. Adult male
Claus Kordes et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31(2-3), 290-304 (2013-03-15)
Hematopoiesis can occur in the liver, when the bone marrow fails to provide an adequate environment for hematopoietic stem cells. Hepatic stellate cells possess characteristics of stem/progenitor cells, but their contribution to hematopoiesis is not known thus far. Isolated hepatic
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）