07-2192

Anti-phospho-TBK1 (Ser172) Antibody

from rabbit, purified by affinity chromatography

• 別名: Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse, human
• 化学種の反応性（ホモロジーによる予測）: rat (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_037386
• UniProtアクセッション番号: Q9UHD2
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: phosphorylation (pSer172)
• 遺伝子情報: human ... TBK1(29110)

詳細

詳細

TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.

特異性

This antibody recognizes TBK1 phosphorylated at Ser172.

免疫原

KLH-conjugated linear peptide corresponding to human TBK1 phosphorylated at Ser172.

アプリケーション

This phospho-TBK1 antibody is validated for use in WB for the detection of the phospho-TBK1 protein.

品質

Evaluated by Western Blot in EGF treated and untreated HEK293 cell lysates.

Western Blot Analysis: 1:1,000 dilution of this antibody detected TBK1 on 10 µg of EGF treated and untreated HEK293 cell lysates.

ターゲットの説明

~90 kDa observed

アナリシスノート

Control
EGF treated and untreated HEK293 cell lysates

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable