14-439-M

MAP Kinase 1/Erk1 Protein, active, 10 µg

Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.

• 別名: ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in E. coli
• フォーム: liquid
• 分子量: M_w 69.9 kDa
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• 色: colorless
• 溶解性: water: soluble
• NCBIアクセッション番号: NM_002745.4; NM_138957.3
• UniProtアクセッション番号: P28482
• 遺伝子情報: human ... MAPK3(5595)

詳細

詳細

Research area: Cell Signaling

Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag

生物化学的／生理学的作用

Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.

包装

Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.

品質

routinely evaluated by phosphorylation of MBP

物理的形状

Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2