5.06072

IWP-2

≥99% (HPLC), liquid, Wnt antagonist, Calbiochem

• 別名: InSolution Wnt Antagonist II, IWP-2, N-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide, Wnt Pathway Inhibitor II InSolution, Inhibitor of Wnt Production-2, Porcn Inhibitor I InSolution, InSolution Wnt Antag
• 実験式（ヒル表記法）: C₂₂H₁₈N₄O₂S₃
• CAS番号: 686770-61-6
• 分子量: 466.60
• MDL番号: MFCD04457599
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: IWP-2, InSolution, ≥99%, 10 mM in DMSO, A cell-permeable benzothiazolyl-acetamide compound, Wnt Antagonist II
• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 保管温度: −70°C
• InChI: 1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
• InChI Key: WRKPZSMRWPJJDH-UHFFFAOYSA-N

詳細

詳細

A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Porcn

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

物理的形状

A 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2 (Cat. No. 681671) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Warming to 60°C may be required upon initial thaw.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - (refers to pure substance)
• 引火点(℃): 87 °C - (refers to pure substance)