5.06188

Sertraline Hydrochloride

• 別名: Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft
• 実験式（ヒル表記法）: C₁₇H₁₇Cl₂N · xHCl
• CAS番号: 79559-97-0
• 分子量: 306.23 (free base basis)
• MDL番号: MFCD00895772
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: solid
• 有効性: 3.3 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mM; ethanol: 50 mM
• 保管温度: 2-8°C
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChI Key: BLFQGGGGFNSJKA-XHXSRVRCSA-N

詳細

詳細

A very potent uptake inhibitor highly selective for serotonin (K_i = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

生物化学的／生理学的作用

Primary Target
5-HT uptake transporter

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS08,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302 - H373 - H410
• 注意書き: P260 - P264 - P273 - P301 + P312 - P314 - P391
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable