由来生物
rabbit
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
rat
メーカー／製品名
Chemicon®
テクニック
ELISA: suitable
輸送温度
dry ice
ターゲットの翻訳後修飾
unmodified
詳細
Homocysteine a sulphur containing amino acid, is formed by the transmethylation of methionine, an essential amino acid. Homocysteine may be irreversibly metabolised to cystathionine by cystathionine synthetase. This reaction uses pyridoxal phosphate (Vitamin B6) as a co-enzyme (see figure). The enzyme cystathionine synthetase is deficient in homocysteinuria, a rare genetic disease associated with high blood levels of homocysteine and the development of premature atherosclerosis. This and the association of other rare enzyme deficiencies with homocysteinemia and premature atherosclerosis led McCully to formulate the homocysteine hypothesis of atherosclerosis (McCully KS, The homocysteine theory of atherosclerosis. Atherosclerosis. 1976; 20: 23-27)
特異性
Homocysteine
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
Homocysteine-G-BSA 1
Cysteine-G-BSA 1/450
Homocysteic acid-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
Homocysteine-G-BSA 1
Cysteine-G-BSA 1/450
Homocysteic acid-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
免疫原
Homocysteine-Glutaraldehyde-BSA
アプリケーション
Research Category
ニューロサイエンス
ニューロサイエンス
Research Sub Category
ニューロフィラメント及び神経細胞代謝
神経変性疾患
ニューロフィラメント及び神経細胞代謝
神経変性疾患
Suggested working dilution: 1:1,000-1:5,000
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
This Anti-Homocysteine Antibody is validated for use in ELISA for the detection of Homocysteine.
物理的形状
Rabbit antiserum. Liquid with 0.05% sodium azide.
保管および安定性
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AB5512:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Hieronim Jakubowski
Physiological reviews, 99(1), 555-604 (2018-11-15)
Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including heart and brain diseases. Earlier studies show that patients with severe hyperhomocysteinemia, first identified in the 1960s
Amany Tawfik et al.
Journal of clinical medicine, 8(1) (2019-01-24)
Diabetic retinopathy (DR) is the most common cause of blindness in people under the age of 65. Unfortunately, the current screening process for DR restricts the population that can be evaluated and the disease goes undetected until irreversible damage occurs.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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