MABN238

Anti-Glucagon Antibody, clone 13D11.33

clone 13D11.33, from mouse

• 別名: 4030-01F, 4031-01F, AB932
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: 13D11.33, monoclonal
• application: ELISA; IF; IHC; multiplexing
• 化学種の反応性: human, rat
• テクニック: ELISA: suitable; immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); multiplexing: suitable
• citations: 11

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 13D11.33, monoclonal
• 化学種の反応性: human, rat
• テクニック: ELISA: suitable; immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); multiplexing: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_002045
• UniProtアクセッション番号: P01275
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GCG(2641)

詳細

詳細

Glucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes.

免疫原

Ovalbumin-conjugated linear peptide corresponding to human Glucagon.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
感覚・末梢神経

Detect Glucagon using this Anti-Glucagon Antibody, clone 13D11.33 validated for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.

Immunohistochemistry Analysis: A 1:8,000 dilution from a representative lot detected Glucagon in normal rat pancreas tissue (For enhanced staining results, it is recommended to use a 10,000 dilution of this antibody.).

ELISA Analysis: A representative lot detected Glucagon in ELISA.

Luminex^® Analysis: A representative lot detected Glucagon in Luminex Assay.

品質

Evaluated by Immunofluorescence in normal rat pancreas tissue.

Immunofluorescence Analysis: A 1:8,000 dilution of this antibody detected Glucagon in normal rat pancreas tissue.

ターゲットの説明

21 kDa calculated

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Normal rat pancreas tissue

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

Luminex is a registered trademark of Luminex Corp

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable