MABT75

Anti-Titin (NT/Z-domain) Antibody, clone 17D11.1

clone 17D11.1, from mouse

• 別名: Titin, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 17D11.1, monoclonal
• 化学種の反応性: human, mouse
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_596870
• UniProtアクセッション番号: Q8WZ42
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TTN(7273)

詳細

詳細

Titin is a large complex protein containing over one hundred IgG-like and fibronectin type-III domains, in addition to multiple Kelch, RCC1, TPR, and WD repeats. It is a member of the CAMK Ser/Thr protein kinase family and also possesses a protein kinase domain, which is involved in controlling gene expression and protein turnover in muscle tissues. Titin also functions as a sensor to mediate appropriate cellular responses to mechanical stress. In striated muscle tissue, titin regulates the length of the sarcomere by integrating myosin and actin filaments at the Z-disk and M-band, and facilitates the elasticity of the sarcomere. Titin also regulates sarcomere assembly and functions as central hub in signal transduction pathways. Defects in Titin may contribute to various forms of cardiomyopathy.

免疫原

GST-tagged recombinant protein corresponding to human Titin.

アプリケーション

Research Sub Category
細胞骨格

Anti-Titin (N-terminal/Z-domain) Antibody, clone 17D11.1 is an antibody against Titin (N-terminal/Z-domain) for use in Western Blotting, IHC(P).

Research Category
Cell Structure

品質

Evaluated by Immunohistochemistry in human and mouse cardiac muscle tissues.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected Titin in human and mouse cardiac muscle tissues.

ターゲットの説明

38 kDa calculated

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Human and mouse cardiac muscle tissues

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable