L2295

抗LRP1 (N-末端) ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗α2-マクログロブリンレセプター抗体, 抗A2MR抗体, 抗APOER抗体, 抗APR抗体, 抗CD91抗体, 抗LRP抗体, 抗アポリポタンパク質Eレセプター抗体, 抗低密度リポタンパク質受容体関連タンパク質1抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~500 kDa
• 化学種の反応性: human, mouse, rat
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: 2-5 μg/mL using rat NRK cells; western blot: 1-2 μg/mL using whole extract of human U87 cells; western blot: 2-4 μg/mL using whole extract of mouse C2C12 cells
• UniProtアクセッション番号: Q07954
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LRP1(4035) ; mouse ... Lrp1(16971) ; rat ... Lrp1(299858)

詳細

詳細

LDL receptor-related protein 1 (LRP1), also known as 2-macroglobulin receptor, is a large endocytic receptor, widely expressed on the surface and intracellular membranes of various cells. LRP1 is encoded by the gene mapped to human chromosome 12q13.3. The encoded protein is a member of the LDL receptor family. LRP1 is synthesized in the endoplasmic reticulum as a single-chain 600 kDa type I transmembrane glycosylated precursor that is cleaved subsequently in the Golgi complex into two subunits of 515 kDa and 85 kDa. The 515 kDa N-terminal subunit remains attached to the membrane through noncovalent association with the smaller 85 kDa C-terminal subunit, which contains the transmembrane and cytoplasmic domains.

特異性

Anti-LRP1 (N-terminal) recognizes human, mouse, and rat LRP1 (not tested in other species).

アプリケーション

Anti-LRP1 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生物化学的／生理学的作用

LRP1 expression is essential for early embryonic development. LRP1 facilitates various biological processes including lipoprotein metabolism, proteinase regulation, lysosomal enzymes activation and entry of viruses and toxins into the cells. In addition, It also regulates cell signaling pathways, cell migration, and neurodevelopment. LRP1 has an ability to bind at least 30 different ligands such as lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. It also binds to bacterial toxins and viruses.

物理的形状

0.01M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

保管および安定性

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable