M265

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 別名: Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
• MDL番号: MFCD01865097
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: lyophilized powder
• 分子量: antigen 180 kDa
• 化学種の反応性: rat, human, mouse
• テクニック: immunohistochemistry (frozen sections): 1:1,000; immunoprecipitation (IP): 3 μL using 200 μg of rat brain; western blot: 1 μg/mL using ³⁵S-Protein A (with ECL dilutions may be higher)
• UniProtアクセッション番号: Q13224
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GRIN2B(2904) ; mouse ... Grin2b(14812) ; rat ... Grin2b(24410)

詳細

詳細

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) codes for N-methyl D-aspartate receptor subtype 2B (GluN2B). It is an important constituent of the N-methyl D-aspartate receptor protein. GRIN2B gene is located on human chromosome 12p13.1.

免疫原

NR2AのC末端部分(アミノ酸984~1104)。

アプリケーション

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is suitable for use in immunohistochemistry (1:1,000 dilution, using frozen sections), immunoprecipitation (3 μL using 200 μg of rat brain), and indirect ELISA. The antibody may also be used for western blot (1 μg/mL using (35S)-Protein A) and immunoblot (180 kDa).

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit has been used in western blotting.

生物化学的／生理学的作用

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) plays a key role in synaptic plasticity, language acquisition, neural pattern formation and short-term memory. Mutations on GRIN2B gene results in Parkinson′s disease, schizophrenia, bipolar disorder, Alzheimer′s disease and obsessive-compulsive disorder.

The functional N-Methyl-D-Aspartate (NMDA) receptor complex consists of a NMDAR1 (NR1) subunit and atleast one NMDAR2 subunit ranging from NR2A-NR2D. These receptor complexes have been implicated in cochlear functions and neuronal plasticity. The C-terminal end of NR2B receptor may regulate synaptic localization.

物理的形状

凍結乾燥品(5 mM炭酸アンモニウム)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)