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Merck

P1495

Sigma-Aldrich

抗ホスファチジルセリンレセプター ウサギ宿主抗体

1-1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

抗PSR抗体

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.41
結合体:
unconjugated
application:
ARR
IP
WB
クローン:
polyclonal
化学種の反応性:
mouse, human
citations:
6
テクニック:
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using whole extracts of human HeLa or A549 cells
western blot: 1:500 using whole extracts of mouse NIH3T3 cells

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen 50-70 kDa

化学種の反応性

mouse, human

濃度

1-1.5 mg/mL

テクニック

immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using whole extracts of human HeLa or A549 cells
western blot: 1:500 using whole extracts of mouse NIH3T3 cells

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... JMJD6(23210)
mouse ... Jmjd6(107817)

関連するカテゴリー

詳細

Phosphatidylserine Receptor (PSR) is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues. It is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.
Phosphatidylserine receptor belongs to the group of Jumonji domain containing protein 6 (JMJD6). It is known to be localized to the phagocytes. PSR is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues.

特異性

Anti-Phosphatidylserine Receptor (PSR) recognizes human and mouse phosphatidylserine receptor (PSR). Detection of the phosphatidylserine receptor by immunoblotting is specifically inhibited by the immunizing peptide, a synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor, conjugated to maleimide-activated KLH as immunogen.

免疫原

synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor conjugated to maleimide-activated KLH. The corresponding sequence in mouse differs by one amino acid.

アプリケーション

Anti-Phosphatidylserine Receptor antibody is sutiable for use in immunoprecipitation and immunoblotting (~50-70 kDa) applications.

生物化学的/生理学的作用

Phosphatidylserine receptor (PSR) is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.

物理的形状

0.01M PBS溶液 (pH 7.4, 1% BSA, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

12 - Non Combustible Liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

P1495-200UL:
P1495-VAR:
P1495-BULK:


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試験成績書(COA)

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases
Fadok VA, et al.
Journal of immunology (Baltimore, Md. : 1950), 166(11), 6847-6854 (2001)
Phosphatidylserine, a death knell
Schlegel RA and Williamson P
Cell Death and Differentiation, 8(6), 551-551 (2001)
Eva Pallinger et al.
Scientific reports, 8(1), 4662-4662 (2018-03-20)
Earlier evidence suggests, that the embryo signals to the maternal immune system. Extracellular vesicles (EVs) are produced by all types of cells, and because they transport different kinds of molecules from one cell to the other, they can be considered
JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4
Wan J, et al.
International Journal of Cancer. Journal International Du Cancer, 144(10), 2489-2500 (2019)
Bianca Cioni et al.
Molecular cancer research : MCR, 21(6), 614-627 (2023-03-04)
Breast cancer is the most common type of cancer in women worldwide, with the luminal subtype being the most widespread. Although characterized by better prognosis compared with other subtypes, luminal breast cancer is still considered a threatening disease due to

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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