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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 50-70 kDa
化学種の反応性
mouse, human
濃度
1-1.5 mg/mL
テクニック
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using whole extracts of human HeLa or A549 cells
western blot: 1:500 using whole extracts of mouse NIH3T3 cells
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... JMJD6(23210)
mouse ... Jmjd6(107817)
関連するカテゴリー
詳細
Phosphatidylserine Receptor (PSR) is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues. It is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.
Phosphatidylserine receptor belongs to the group of Jumonji domain containing protein 6 (JMJD6). It is known to be localized to the phagocytes. PSR is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues.
特異性
Anti-Phosphatidylserine Receptor (PSR) recognizes human and mouse phosphatidylserine receptor (PSR). Detection of the phosphatidylserine receptor by immunoblotting is specifically inhibited by the immunizing peptide, a synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor, conjugated to maleimide-activated KLH as immunogen.
免疫原
synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor conjugated to maleimide-activated KLH. The corresponding sequence in mouse differs by one amino acid.
アプリケーション
Anti-Phosphatidylserine Receptor antibody is sutiable for use in immunoprecipitation and immunoblotting (~50-70 kDa) applications.
生物化学的/生理学的作用
Phosphatidylserine receptor (PSR) is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.
物理的形状
0.01M PBS溶液 (pH 7.4, 1% BSA, 15mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P1495-200UL:
P1495-VAR:
P1495-BULK:
Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases
Journal of immunology (Baltimore, Md. : 1950), 166(11), 6847-6854 (2001)
Phosphatidylserine, a death knell
Cell Death and Differentiation, 8(6), 551-551 (2001)
Scientific reports, 8(1), 4662-4662 (2018-03-20)
Earlier evidence suggests, that the embryo signals to the maternal immune system. Extracellular vesicles (EVs) are produced by all types of cells, and because they transport different kinds of molecules from one cell to the other, they can be considered
JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4
International Journal of Cancer. Journal International Du Cancer, 144(10), 2489-2500 (2019)
Molecular cancer research : MCR, 21(6), 614-627 (2023-03-04)
Breast cancer is the most common type of cancer in women worldwide, with the luminal subtype being the most widespread. Although characterized by better prognosis compared with other subtypes, luminal breast cancer is still considered a threatening disease due to
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