SAB2500781

抗PGC1A抗体 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗LEM6抗体, 抗PPARGC1A抗体, 抗ペルオキシソーム増殖因子活性化レセプターγ抗体
• MDL番号: MFCD02263906
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); WB
• クローン: polyclonal
• 化学種の反応性: human, mouse, canine, rat
• citations: 8
• テクニック: indirect ELISA: suitable; western blot: suitable

特性

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: human, mouse, canine, rat
• テクニック: indirect ELISA: suitable; western blot: suitable
• UniProtアクセッション番号: Q9UBK2
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PPARGC1A(10891)

詳細

詳細

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.

免疫原

NP_037393.1によるタンパク質配列の内部領域に由来するペプチド(C-DGLFDDSEDESDK)。

アプリケーション

Anti-PGC1A antibody produced in goat has been used in Western blotting.

生物化学的／生理学的作用

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘molecular switch′ in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

0.5 mg/mL Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable