SAB2900383

Anti-SFRP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: frza, sarp2, secreted frizzled related protein, sfrp-1
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IF; IHC (p); WB
• クローン: polyclonal
• 化学種の反応性: mouse, human
• citations: 8
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect immunofluorescence: suitable; western blot: suitable

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: mouse, human
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect immunofluorescence: suitable; western blot: suitable
• UniProtアクセッション番号: Q8N474
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SFRP1(6422)

詳細

詳細

SFRP1 (secreted frizzled-related protein 1) is a 35.4 kDa antagonist protein.
The encoded protein by SFRP1 gene has a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors. It belongs to the WNT pathway. This gene is located on human chromosome 8p12–11.1.

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

免疫原

Synthetic peptide from human SFRP1.

アプリケーション

Anti-SFRP1 antibody has been used in western blot analysis.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生物化学的／生理学的作用

SFRP1 (secreted frizzled-related protein 1) plays a major role in the progression of several malignancies. It also plays a vital role in antagonizing Wnt signaling. Overexpression of SFRP1 is linked with apoptosis.

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

特徴および利点

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物理的形状

PBS溶液(pH 7.2, 0.01%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable