SAB3500199
Anti-Clusterin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
別名:
抗ApoJ抗体, 抗CLI抗体, 抗アポリポタンパク質J抗体
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すべての画像(5)
About This Item
結合体:
unconjugated
application:
ELISA (i)
IF
IHC
WB
IF
IHC
WB
クローン:
polyclonal
化学種の反応性:
human, mouse
citations:
7
テクニック:
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human, mouse
テクニック
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CLU(1191)
詳細
The Clusterin (CLU) gene is mapped to human chromosome 8p21.1. The encoded protein is a chaperone and is conserved along with evolution. It is present in human tissues and fluids.
免疫原
Clusterin antibody was raised recombinant human Clusterin isoform 1.
アプリケーション
Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100).
生物化学的／生理学的作用
Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small heat shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimer′s disease (LOAD).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS（0.02％ アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Prakash Priyadarshi Praharaj et al.
Biochimica et biophysica acta. Reviews on cancer, 1875(2), 188500-188500 (2021-01-02)
Clusterin (CLU) is an evolutionary conserved molecular chaperone present in different human tissues and fluids and established to be a significant cancer regulator. It controls several cancer-associated cellular events, including cancer cell proliferation, stemness, survival, metastasis, epithelial-mesenchymal transition, therapy resistance
Katina M Athanas et al.
Schizophrenia research, 169(1-3), 381-385 (2015-10-21)
The expression of the gene that encodes clusterin, a glycoprotein that has been implicated in the regulation of many cellular processes, has previously been found in gene expression profiling studies to be among the most significantly differentially expressed genes in
Vladimir J Balcar et al.
Neurochemical research, 46(2), 411-422 (2020-11-19)
Clusterin (CLU; also known as apolipoprotein J, ApoJ) is a protein of inconstant structure known to be involved in diverse processes inside and outside of brain cells. CLU can act as a protein chaperon or protein solubilizer, lipid transporter as
Sarah M Carpanini et al.
Genes, 12(3) (2021-04-04)
Late-onset Alzheimer's disease (LOAD), the most common cause of dementia, and a huge global health challenge, is a neurodegenerative disease of uncertain aetiology. To deliver effective diagnostics and therapeutics, understanding the molecular basis of the disease is essential. Contemporary large
Ahmed A Moustafa et al.
Reviews in the neurosciences, 29(1), 21-38 (2017-09-28)
In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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