SAB4200039

抗セロトニントランスポーター (N-末端) ウサギ宿主抗体

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗5-ヒドロキシトリプタミン輸送体抗体, 抗5HTT抗体, 抗HTT抗体, 抗OCD1抗体, 抗SERT抗体, 抗SLC6A4溶質キャリアファミリー6, メンバー4抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~83 kDa
• 交差性: human
• 濃度: ~1.5 mg/mL
• テクニック: western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates
• UniProtアクセッション番号: P31645
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rat ... Slc6a4(25553)

詳細

詳細

Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.

アプリケーション

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

生物化学的／生理学的作用

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increases the risk of susceptibility to autism and rigid-compulsive behaviors.

The polymorphic promoter region of the serotonin transporter gene serotonin-transporter-linked polymorphic region (5HTTLPR), has been suggested to affect serotonin uptake and may play a role in the pathogenesis of depression, obsessive-compulsive disorder (OCD) and aggressive behavior.

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable