SAB4500433

Anti-Claudin 4 antibody produced in rabbit

affinity isolated antibody

• 別名: CLD4, CLDN4, CPE- receptor, Claudin-4, Clostridium perfringens enterotoxin receptor
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA; IHC; WB
• クローン: polyclonal
• 化学種の反応性: rat, mouse, human
• citations: 5
• テクニック: ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 22 kDa
• 化学種の反応性: rat, mouse, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBIアクセッション番号: O14493
• UniProtアクセッション番号: O14493
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CLDN4(1364)

詳細

詳細

The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.

免疫原

The antiserum was produced against synthesized peptide derived from human Claudin 4.

Immunogen Range: 160-209

生物化学的／生理学的作用

CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable