SAB4503051

Anti-Tyrosinase antibody produced in rabbit

affinity isolated antibody

• 別名: TYR
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 60 kDa
• 交差性: human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBIアクセッション番号: P14679
• UniProtアクセッション番号: P14679
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TYR(7299)

詳細

詳細

Anti-Tyrosinase Antibody detects endogenous levels of total Tyrosinase protein.

The TYR (tyrosinase) gene is mapped to human chromosome 11q14.3 and codes for a membrane glycoprotein, tyrosinase. It is ubiquitously expressed in plant and animal tissue.

免疫原

The antiserum was produced against synthesized peptide derived from human Tyrosinase.

Immunogen Range: 471-520

生物化学的／生理学的作用

The encoded protein, tyrosinase, is involved in melanin production by catalyzing the oxidation of L-tyrosine and L- 3, 4-dihydroxyphenylalanine to form dopaquinone. TYR (tyrosinase) is associated with the development of neural crest cell into melanocytes. Biallelic mutations in the TYR gene results in an autosomal recessive disorder, oculocutaneous albinism type 1. Loss of tyrosinase activity contributes to the severity of this disorder, in which melanin is undetectable. Abnormal expression of the gene has been observed in atypical fibroxanthoma.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable