おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 61 kDa
交差性
mouse, rat, human
濃度
~1 mg/mL
テクニック
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
phosphorylation (pSer176)
遺伝子情報
human ... RIPK2(8767)
詳細
Receptor interacting protein kinase 2 (RIP2K) has an N-terminal dual-specificity ser/tyr kinase domain. This gene is a member of the TKL kinase family (tyrosine kinase-like). RIP2K is located on human chromosome 8q21.
免疫原
The antiserum was produced against synthesized peptide derived from human RIPK2 around the phosphorylation site of Ser176.
Immunogen Range: 146-195
Immunogen Range: 146-195
生物化学的／生理学的作用
Receptor interacting protein kinase 2 (RIP2K) can act as a new target for anti-inflammatory drugs. This gene participates in multiple nuclear factor-κB (NFκB) activation pathways and human colon tumorigenesis.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4504642-100UG:
最新バージョンのいずれかを選択してください：
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation
Pellegrini E, et al.
PLoS ONE, 12(5) (2017)
Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function
Rodrigue-Gervais IG and Saleh M
European Journal of Immunology, 40(3), 643-648 (2010)
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study
Posadas-Sanchez R, et al.
Experimental and Molecular Pathology, 102(1), 1-6 (2017)
Ravi Bharadwaj et al.
Immunity, 56(5), 998-1012 (2023-04-29)
Cytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall. These muropeptides enter cells, especially epithelial cells, through unclear mechanisms. We previously implicated
Huisheng Liu et al.
Journal of virology, 93(11) (2019-03-22)
The role of nucleotide-binding oligomerization domain 2 (NOD2) in foot-and-mouth disease virus (FMDV)-infected cells remains unknown. Here, we showed that FMDV infection activated NOD2-mediated beta interferon (IFN-β) and nuclear factor-κB (NF-ĸB) signaling pathways. NOD2 inhibited FMDV replication in the infected
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