おすすめの製品
アッセイ
≥98% (HPLC)
品質水準
形状
powder
保管条件
desiccated
色
white to tan
溶解性
DMSO: ≥5 mg/mL
保管温度
2-8°C
SMILES記法
CCc1ccc(cc1)-c2nc(CSCC(=O)NCCc3ccccc3)c(C)o2
InChI
1S/C23H26N2O2S/c1-3-18-9-11-20(12-10-18)23-25-21(17(2)27-23)15-28-16-22(26)24-14-13-19-7-5-4-6-8-19/h4-12H,3,13-16H2,1-2H3,(H,24,26)
InChI Key
QTDYVSIBWGVBKU-UHFFFAOYSA-N
詳細
iCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.
アプリケーション
iCRT3 has been used to inhibit the interactions between β-catenin and transcription factor (TCF).
iCRT3 has been used:
- for β- catenin inhibition in dual luciferase assay
- to inhibit β-catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)(3)catenin inhibition in dual luciferase assay
- to inhibit β- catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)
生物化学的／生理学的作用
The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML0211-BULK:
SML0211-VAR:
SML0211-25MG:
SML0211-IP:
SML0211-5MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wntbeta-catenin signaling
Sharma A, et al.
Scientific reports, 7(1), 9235-9235 (2017)
Increasing beta-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis
Benham-Pyle BW, et al.
eLife, 5, e19799-e19799 (2016)
UVB represses melanocyte cell migration and acts through beta-catenin
Bertrand JU, et al.
Experimental Dermatology, 26(10), 875-882 (2017)
Archna Sharma et al.
Scientific reports, 7(1), 9235-9235 (2017-08-25)
The Wnt/β-catenin pathway has been involved in regulating inflammation in various infectious and inflammatory diseases. Sepsis is a life-threatening condition caused by dysregulated inflammatory response to infection with no effective therapy available. Recently elevated Wnt/β-catenin signaling has been detected in
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wntbeta-Catenin Signaling
Cha B, et al.
Testing, 25(3), 571-584 (2018)
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