SML0416

TCN-201

≥98% (HPLC)

• 別名: 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide
• 実験式（ヒル表記法）: C₂₁H₁₇ClFN₃O₄S
• CAS番号: 852918-02-6
• 分子量: 461.89
• MDL番号: MFCD06683895
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825411
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL (clear solution)
• 保管温度: 2-8°C
• SMILES記法: Fc1ccc(cc1Cl)S(=O)(=O)NCc2ccc(cc2)C(=O)NNC(=O)c3ccccc3
• InChI: 1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
• InChI Key: FYIBXBFDXNPBSF-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

TCN-201 is a NR2A-selective NMDAreceptor antagonist 1.

TCN-201 is a sulphonamide derivative, that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor.

TCN-201 is the first NMDA receptor antagonist that is specific for NR2A-subunit containing receptors. The pIC₅₀ for NR2A NMDA receptors is 6.8. TCN-201has no effect on NR2B-containing receptors at concentrations up to 50 mM.

特徴および利点

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335,H336
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Central nervous system, Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable