SML2422

Sophocarpine

≥95% (HPLC)

• 別名: (-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC
• 実験式（ヒル表記法）: C₁₅H₂₂N₂O
• CAS番号: 6483-15-4
• 分子量: 246.35
• MDL番号: MFCD00274555
• UNSPSCコード: 12352200

特性

• 由来生物: Sophora alopecuroides
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 光学活性: [α]/D -26 to -35°, c = 0.5 in ethanol
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• InChI: 1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1
• InChI Key: NBBQEIQEBNYSFK-PUILLJIJSA-N

詳細

生物化学的／生理学的作用

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable