SML3438

NDI-091143

≥90% (HPLC)

• 別名: 3-Chloro-5-[[(4,6-difluoro[1,1′-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-benzoic acid, methyl ester, Methyl 3-chloro-5-[(2,4-difluoro-5-phenylphenyl) sulfamoyl]-4-hydroxybenzoate, NDI 091143, NDI091143
• 実験式（ヒル表記法）: C₂₀H₁₄ClF₂NO₅S
• CAS番号: 2375840-87-0
• 分子量: 453.84
• MDL番号: MFCD32644582
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

NDI-091143 is a highly potent, allosteric ATP-citrate lyase inhibitor (human ACLY IC50 = 4.8 nM by coupled enzyme assay with 85 μM citrate; IC50 = 2.1 nM by ADP-Glo assay) that indirectly disrupts citrate binding (Ki = 7 nM) by targeting an adjacent hydrophobic site (kon = 1.02 x 10^6/M/s, koff = 0.0019/s).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable