SRP8054

Tim-1 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 別名: Hepatitis A virus cellular receptor 1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD1
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: human
• リコンビナント: expressed in CHO cells
• アッセイ: ≥98% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: monomer 57 kDa by calculation
• 包装: pkg of 100 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: <0.06 EU/μg endotoxin, tested
• 色: white
• UniProtアクセッション番号: Q96D42
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... HAVCR1(26762)

詳細

詳細

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

物理的形状

Lyophilized from 0.2 μm-filtered solution in PBS.

再構成

Reconstitute at 100 μg/mL in sterile PBS.

その他情報

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable