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About This Item
実験式（ヒル表記法）:
C11H7F3O3
CAS番号:
分子量:
244.17
Beilstein:
225039
MDL番号:
UNSPSCコード:
12352204
PubChem Substance ID:
NACRES:
NA.32
おすすめの製品
アッセイ
≥99% (TLC)
形状
powder
溶解性
acetone: 50 mg/mL, clear, colorless to faintly yellow
蛍光検出
λex 333 nm; λem 416 nm in methanol
SMILES記法
COc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3
InChI Key
HAZHUELNIGDYQH-UHFFFAOYSA-N
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アプリケーション
7-Methoxy-4-(trifluoromethyl)coumarin has been used as a substrate in cytochrome P450 2E1 (CYP2E1) activity assay and aromatase assay.
生物化学的／生理学的作用
The enzymatic action of cytochrome P450 2E1 (CYP2E1) on 7-methoxy-4-(trifluoromethyl)coumarin results in a fluorescent product 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) that can be measured at 409/530 nm.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T3165-BULK:
T3165-25MG:
T3165-100MG:
T3165-VAR:
T3165-500MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Rebeca Santes-Palacios et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 105009-105009 (2020-10-03)
Cytochrome P450 2E1 (CYP2E1) has been proposed as a molecular target in oxidative stress-associated metabolic diseases. Rats are chosen as model organisms in most experiments studying CYP2E1-related toxicity; however, the human relevance of these results remains unclear. To describe differences
Carlo Matera et al.
European journal of pharmacology, 820, 265-273 (2017-12-25)
(±)-3-Methoxy-1-oxa-2,7-diaza-7,10-ethanospiro[4.5]dec-2-ene sesquifumarate (±)-1 was previously characterized as the most selective agonist at α7 neuronal nicotinic acetylcholine receptors in a series of spirocyclic quinuclidinyl-Δ
Thomas Piper et al.
Drug testing and analysis, 13(5), 916-928 (2020-12-08)
The steroid profile, that is, the urinary concentrations and concentration ratios of selected steroids, is used in sports drug testing to detect the misuse of endogenous steroids such as testosterone. Since several years, not only population-based thresholds are applied but
Gaku Okamatsu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(2), 93-102 (2016-03-10)
1. Little is known about drug metabolism in carnivores. Although the domestic cat (Felis catus) is an obligate carnivore and is the most common companion animal, usage and dosage of many drugs are determined according to information obtained from humans and
Yuka Ono et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(6), 627-635 (2018-06-01)
1. Compared to information for herbivores and omnivores, knowledge on xenobiotic metabolism in carnivores is limited. The cytochrome P450 2C (CYP2C) subfamily is recognized as one of the most important CYP groups in human and dog. We identified and characterized
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