1286413

Frovatriptan succinate

United States Pharmacopeia (USP) Reference Standard

• 別名: Frovatriptan succinate monohydrate, Frovatriptan succinate, R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate
• 実験式（ヒル表記法）: C₁₄H₁₇N₃O · C₄H₆O₄ · H₂O
• CAS番号: 158930-17-7
• 分子量: 379.41
• MDL番号: MFCD18251278
• UNSPSCコード: 41116107
• PubChem Substance ID: 329749910
• NACRES: NA.24

特性

• グレード: pharmaceutical primary standard
• APIファミリー: frovatriptan
• メーカー／製品名: USP
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• SMILES記法: OC(CCC(O)=O)=O.NC(C(C=C1)=CC2=C1NC3=C2C[C@H](NC)CC3)=O.O
• InChI: 1S/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2/t9-;;/m1../s1
• InChI Key: CUETXFMONOSVJA-KLQYNRQASA-N
• 遺伝子情報: human ... HTR1B(3351) , HTR1D(3352)

詳細

詳細

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

アプリケーション

Frovatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生物化学的／生理学的作用

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC₅₀ value of 8.2 for the 5-HT1B receptor, compared to a pEC₅₀ value of 6.2 for the 5-HT7 receptor.

アナリシスノート

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

その他情報

Sales restrictions may apply.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable