- A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds.
A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds.
Molecules (Basel, Switzerland) (2019-12-19)
Elena Chiurchiù, Serena Gabrielli, Roberto Ballini, Alessandro Palmieri
PMID31847286
要旨
Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps promoted by solid supported species, and it provides the title targets from satisfactory to very good overall yields and in an excellent diastereomeric ratios.
材料
製品番号
ブランド
製品内容
Sigma-Aldrich
4-(ジメチルアミノ)ピリジン、ポリマー担持型, extent of labeling: ~3.0 mmol/g "DMAP" loading, matrix crosslinked with 2% DVB
Sigma-Aldrich
2-tert-ブチルアミノ-2-ジエチルアミノ-1,3-ジメチル-ペルヒドロ-1,3,2-ジアザホスホリン, ポリスチレン担持, extent of labeling: ~2.2 mmol/g base loading