- Asymmetric pericyclic cascade approach to spirocyclic oxindoles.
Asymmetric pericyclic cascade approach to spirocyclic oxindoles.
Organic letters (2012-05-16)
Edward Richmond, Nicolas Duguet, Alexandra M Z Slawin, Tomáš Lébl, Andrew D Smith
PMID22583112
要旨
The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.
材料