Manganese neurotoxicity and the role of reactive oxygen species.

Manganese neurotoxicity and the role of reactive oxygen species.

Free radical biology & medicine (2013-02-12)

Ebany J Martinez-Finley, Claire E Gavin, Michael Aschner, Thomas E Gunter

要旨

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

材料

製品番号

ブランド

製品内容

463728

Sigma-Aldrich

マンガン, powder, ≥99.9% trace metals basis

266132

Sigma-Aldrich

マンガン, powder, −325 mesh, ≥99% trace metals basis

266167

Sigma-Aldrich

マンガン, chips, thickness <2.0 mm, 99%

GF83932768

マンガン, foil, 25x25mm, thickness 2mm, hot-pressed, 99.95%

GF94645233

マンガン, foil, not light tested, 50x50mm, thickness 0.025mm, permanent polyester support, 98.7%

GF11021094

マンガン, rod, 10mm, diameter 4.0mm, cast, 99.5%

GF38495885

マンガン, rod, 50mm, diameter 4.0mm, cast, 99.5%

GF42039918

マンガン, rod, 50mm, diameter 6.35mm, cast, 99.5%

GF87355334

マンガン, foil, 50x50mm, thickness 2mm, hot-pressed, 99.95%

GF81243929

マンガン, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 98.7%

GF24430395

マンガン, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 98.7%

GF05008092

マンガン, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 98.7%

GF00832081

マンガン, foil, not light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 98.7%

GF58094635

マンガン, foil, not light tested, 25x25mm, thickness 0.004mm, permanent polyester support, 98.7%

GF70110593

マンガン, foil, not light tested, 25x25mm, thickness 0.006mm, permanent polyester support, 98.7%

GF94007594

マンガン, foil, not light tested, 25x25mm, thickness 0.003mm, permanent polyester support, 98.7%

GF28884549

マンガン, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 98.7%

GF27632055

マンガン, foil, not light tested, 50x50mm, thickness 0.05mm, permanent polyester support, 98.7%

GF90559794

マンガン, foil, not light tested, 25x25mm, thickness 0.02mm, permanent polyester support, 98.7%

GF41613690

マンガン, foil, not light tested, 25x25mm, thickness 0.007mm, permanent polyester support, 98.7%

GF53469142

マンガン, foil, not light tested, 25x25mm, thickness 0.008mm, permanent polyester support, 98.7%

GF94542206

マンガン, foil, not light tested, 25x25mm, thickness 0.0125mm, permanent polyester support, 98.7%

GF03428625

マンガン, foil, not light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 98.7%

GF31519975

マンガン, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 98.7%

GF40287258

マンガン, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 98.7%

GF92898983

マンガン, foil, not light tested, 25x25mm, thickness 0.009mm, permanent polyester support, 98.7%

GF74177736

マンガン, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 98.7%

GF99005193

マンガン, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 98.7%

GF64815239

マンガン, foil, not light tested, 50x50mm, thickness 0.002mm, permanent polyester support, 98.7%

GF60677646

マンガン, foil, not light tested, 50x50mm, thickness 0.0025mm, permanent polyester support, 98.7%