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Merck
모든 사진(2)

주요 문서

373605

Sigma-Aldrich

6,6′-Dithiodinicotinic acid

technical grade, 85%

동의어(들):

Bis[3-Carboxypyridine] 6,6′-disulfide, Bis[3-carboxypyridine] 6,6′-disulfide

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About This Item

실험식(Hill 표기법):
C12H8N2O4S2
CAS Number:
Molecular Weight:
308.33
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

Grade

technical grade

분석

85%

양식

solid

mp

263-265 °C (lit.)

작용기

carboxylic acid
disulfide

SMILES string

OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1

InChI

1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)

InChI key

GSASOFRDSIKDSN-UHFFFAOYSA-N

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일반 설명

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

애플리케이션

6,6′-Dithiodinicotinic acid may be employed as:
  • specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
  • modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
  • dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
  • water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
  • chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
  • spectrophotometric determination of thiols and of total glutathione in human blood

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

P D Dass et al.
Veterinary and human toxicology, 39(1), 11-17 (1997-02-01)
A kinetic analysis of the substitution of 6,6'-dithiodinicotinic acid (DTNA) for 5,5'-dithiobis-2-nitrobenzoic acid (DTNB) for the determination of rat and human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7) and plasma butyrylcholinesterase (BuChE; EC 3.1.1.8) is presented. Increasing concentrations of DTNB, but not
Metastases limited.
D R Grassetti
Nature, 308(5959), 500-500 (1984-04-05)
M M Konstantinova et al.
Radiobiologiia, 28(3), 364-368 (1988-05-01)
In experiments with Ehrlich ascites tumor cells, using a specific thiol blocker, 6,6'-dithiodinicotinic acid, that does not penetrate the cell and therefore only binds SH-groups of peripheral areas of an external cell membrane, it was demonstrated that (1) the external
J Nandi et al.
The Biochemical journal, 213(3), 587-594 (1983-09-01)
The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gastric (H+ + K+)-transporting ATPase system was investigated. Two
The determination of thiols and of total glutathione in human blood using 6,6'-dithiodinicotinic acid (CPDS).
D R Grassetti et al.
Biochemical medicine, 12(2), 149-153 (1975-02-11)

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