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Merck
모든 사진(1)

주요 문서

467154

Sigma-Aldrich

N-(tert-Butoxycarbonyl)-L-cysteine methyl ester

97%, for peptide synthesis

동의어(들):

N-Boc-L-cysteine methyl ester

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About This Item

Linear Formula:
HSCH2CH[NHCO2C(CH3)3]CO2CH3
CAS Number:
Molecular Weight:
235.30
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22

product name

N-(tert-Butoxycarbonyl)-L-cysteine methyl ester, 97%

Quality Level

분석

97%

형태

liquid

광학 활성

[α]22/D +21°, c = 7.5 in chloroform

반응 적합성

reaction type: solution phase peptide synthesis

refractive index

n20/D 1.475 (lit.)

bp

214 °C (lit.)

density

1.143 g/mL at 25 °C (lit.)

응용 분야

peptide synthesis

SMILES string

COC(=O)[C@H](CS)NC(=O)OC(C)(C)C

InChI

1S/C9H17NO4S/c1-9(2,3)14-8(12)10-6(5-15)7(11)13-4/h6,15H,5H2,1-4H3,(H,10,12)/t6-/m0/s1

InChI key

NJGIAKIPSDCYAC-LURJTMIESA-N

애플리케이션

N-(tert-Butoxycarbonyl)-L-cysteine methyl ester is an N-terminal protected reagent that can be used in the synthesis of peptides and proteins containing cysteine residues, which can further be converted to dehydroalanine.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

235.4 °F - closed cup

Flash Point (°C)

113 °C - closed cup


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문서 라이브러리 방문

Inactivation of NF-κB components by covalent binding of (−)-dehydroxymethylepoxyquinomicin to specific cysteine residues.
Yamamoto M, et al.
Journal of Medicinal Chemistry, 51(18), 5780-5788 (2008)
Methods for converting cysteine to dehydroalanine on peptides and proteins.
Chalker J M, et al.
Chemical Science, 2(9), 1666-1676 (2011)
Igor Linhart et al.
Archives of toxicology, 91(10), 3317-3325 (2017-03-12)
3-Nitrobenzanthrone (3-NBA), a potent environmental mutagen and carcinogen, is known to be activated in vivo to 3-benzanthronylnitrenium ion which forms both NH and C2-bound adducts with DNA and also reacts with glutathione giving rise to urinary 3-aminobenzanthron-2-ylmercapturic acid. In this
An insight into the radical thiol/yne coupling: the emergence of arylalkyne-tagged sugars for the direct photoinduced glycosylation of cysteine-containing peptides.
Minozzi M, et al.
The Journal of Organic Chemistry, 76(2), 450-459 (2010)

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