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일반 설명
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
애플리케이션
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
특징 및 장점
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
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Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
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문서
Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.
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