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Merck
모든 사진(1)

주요 문서

774405

Sigma-Aldrich

(S)-2-Aminobutane-1,4-dithiol hydrochloride

99% (titration)

동의어(들):

(S)-2-Aminobutane-1,4-dithiol hydrochloride, (2S)-2-Amino-1,4-dimercaptobutane hydrochloride, DTBA, Dithiobutylamine

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About This Item

실험식(Hill 표기법):
C4H11NS2 · HCl
CAS Number:
Molecular Weight:
173.73
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.22

Quality Level

분석

99% (titration)

형태

solid

반응 적합성

reagent type: reductant

mp

210-225 °C

저장 온도

2-8°C

SMILES string

Cl.N[C@H](CS)CCS

InChI

1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1

InChI key

HWWPXJZINVJNBM-WCCKRBBISA-N

애플리케이션

(S)-2-Aminobutane-1,4-dithiol hydrochloride (DTBA), also known as dithiobutylamine, is a biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.
Dithiobutylamine or DTBA is a new biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Mozhdeh Imaninezhad et al.
Bioconjugate chemistry, 30(1), 34-46 (2018-12-19)
Macroporous cell-laden hydrogels have recently gained recognition for a wide range of biomedical and bioengineering applications. There are various approaches to create porosity in hydrogels, including lyophilization or foam formation. However, many do not allow a precise control over pore
A potent, versatile disulfide-reducing agent from aspartic acid.
Lukesh III, et al.
Journal of the American Chemical Society, 134(9), 4057-4059 (2012)
Javier Troyano et al.
Inorganic chemistry, 58(5), 3290-3301 (2019-02-13)
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3I3(TBA)2] n (4)
Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent.
Adamczyk J, et al.
Inorganic Chemistry, 54(2), 596-606 (2014)
Sean B Johnston et al.
PloS one, 10(1), e0116898-e0116898 (2015-01-22)
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) is a lipid phosphatase tumor suppressor that is lost or inactivated in most human tumors. The enzyme catalyzes the hydrolysis of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) to form phosphatidylinositol-(4,5)-bisphosphate (PIP2) and inorganic phosphate. Here

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