925624
Redox Responsive Poly(ethylene glycol)-block-poly(ε-caprolactone)
PEG average Mn 5,000, PCL Mn 15,000
동의어(들):
Block copolymer, PEG-PCL with disulfide linkage, PEG-SS-PCL, Stimuli-responsive
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모든 사진(1)
About This Item
Linear Formula:
CH3O(C2H4O)nC7H12O4S2(C6H10O2)
UNSPSC 코드:
12352112
NACRES:
NA.23
추천 제품
양식
solid (could be powder/granules/chunks)
Quality Level
분자량
PCL Mn 15,000
PEG average Mn 5,000
색상
white to beige, light yellow
저장 온도
2-8°C
애플리케이션
PEG-SS-PCL is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(ε-caprolactone) (PCL) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Philip Grossen et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at
pH/redox dual-sensitive nanoparticles based on the PCL/PEG triblock copolymer for enhanced intracellular doxorubicin release.
Cao Y, et al.
Royal Society of Chemistry Advances, 5, 28060-28069 (2015)
문서
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
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