추천 제품
Quality Level
저장 온도
−20°C
애플리케이션
The NanoFabTx™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.
특징 및 장점
- A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- Optimized lipid blend for DBCO-modified protein or antibody conjugation
- Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation
법적 정보
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Li Shen et al.
ACS omega, 5(23), 14111-14115 (2020-06-23)
Two Ac4ManNAz (AAM) derivatives with octadecanoic ester (C18 ester) and octadecyl ether (C18 ether) attached to the anomeric hydroxyl groups were synthesized and used in preparation of liposomes. Both liposomes show strong cell-labeling efficiencies on MDA-MB-231 cancer cells. The cell
Lin Wang et al.
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Nature communications, 9(1), 2612-2612 (2018-07-06)
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Colloids and surfaces. B, Biointerfaces, 182, 110362-110362 (2019-07-28)
Liposomal formulations have important therapeutic applications in anti-cancer treatments but current formulations suffer from serious side effects, high dosage requirements and prolonged treatment. In this study, PEGylated azide-functionalized liposomes containing drug nanocrystals were investigated with the aim of increasing the
Elizabeth D Hood et al.
Bioconjugate chemistry, 29(11), 3626-3637 (2018-09-22)
Liposomes are a proven, versatile, and clinically viable technology platform for vascular delivery of drugs and imaging probes. Although targeted liposomes have the potential to advance these applications, complex formulations and the need for optimal affinity ligands and conjugation strategies
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