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Merck
모든 사진(1)

주요 문서

933899

Sigma-Aldrich

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

동의어(들):

Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan

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About This Item

Linear Formula:
(C12H25N2O5Cl)n(C8H13NO5)m
UNSPSC 코드:
12352201
NACRES:
NA.21

설명

NMR: Conforms to structure

Quality Level

형태

(solid, chunks or fiber)

색상

white to off-white

저장 온도

2-8°C

일반 설명

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

애플리케이션

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

특징 및 장점

Water soluble
Cationically modified
Naturally derived and biocompatible

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for
Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride
Chi W, et al.
Journal of Applied Polymer Science, 103, 3851-3856 (2007)
Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Kai Zhao et al.
Vaccines, 9(9) (2021-09-29)
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on the association with potent adjuvants that can enhance the immunogenicity of antigen and activate the immune

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