D178454

Dimethyl phosphite

98%

• 동의어(들): Dimethoxyphosphine oxide, Dimethyl hydrogen phosphite, Dimethyl hydrogen phosphonate, Dimethyl phosphonate, Hydrogen dimethyl phosphite
• Linear Formula: (CH₃O)₂P(O)H
• CAS Number: 868-85-9
• Molecular Weight: 110.05
• Beilstein: 1697490
• EC Number: 212-783-8
• MDL number: MFCD00044633
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24893543
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: 98%
• 형태: liquid
• 불순물: ≤0.5% trimethyl phosphate; ≤1% methyl alcohol
• refractive index: n20/D 1.402 (lit.)
• bp: 170-171 °C (lit.)
• density: 1.2 g/mL at 25 °C (lit.)
• SMILES string: [H]P(=O)(OC)OC
• InChI: 1S/C2H7O3P/c1-4-6(3)5-2/h6H,1-2H3
• InChI key: HZCDANOFLILNSA-UHFFFAOYSA-N

설명

애플리케이션

Dimethyl phosphite is used in the synthesis of α-aminophosphonates, which are medicinally important phosphorus analogs of amino acids, by treating with an amine and an aldehyde or a ketone. It can also be employed in asymmetric hydrophosphonylation of aldehydes to synthesize optically active α-hydroxy phosphonates.

Dimethyl phosphite may be used as an effective alternative to organic tin hydrides as radical reducing agents for organic halides, thionoesters, and isocyanides to form the corresponding hydrocarbons. Radical translocation/cyclization reactions of terminal alkynes to form cyclic phosphonates can also be effectively carried using dimethyl phosphite as a reagent under tin-free condition.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317,H341,H351,H412
• 예방조치 성명서: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 158.0 °F - closed cup
• Flash Point (°C): 70 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter