P2066

Poly(D,L-lactide-co-glycolide)

lactide:glycolide 65:35, M_w 40,000-75,000

• 동의어(들): Lactel^® B6001-1, PLGA
• Linear Formula: [C₃H₄O₂]_x[C₂H₂O₂]_y
• MDL number: MFCD00131930
• UNSPSC 코드: 12162002
• PubChem Substance ID: 24898268
• NACRES: NA.23

속성

• 형태: pellets
• Quality Level: 100
• 피드(feed) 비율: lactide:glycolide 65:35
• 분자량: M_w 40,000-75,000
• 저장 온도: −20°C
• SMILES string: OCC(O)=O.CC(O)C(O)=O

설명

애플리케이션

• Inhaled Macrophage Apoptotic Bodies-Engineered Microparticle Enabling Construction of Pro-Regenerative Microenvironment to Fight Hypoxic Lung Injury in Mice.: This study demonstrates the use of Poly(ᴅ,ʟ-lactide-co-glycolide) (PLGA) in engineering microparticles that promote lung tissue regeneration in hypoxic conditions, highlighting its potential in developing advanced therapeutic strategies for respiratory injuries (Liu et al., 2024).


• Engineered nanoparticles promote cardiac tropism of AAV vectors.: The research explores the role of PLGA nanoparticles in enhancing the targeting efficiency of AAV vectors to cardiac tissues, showcasing its application in gene therapy and cardiovascular disease treatment (Switala et al., 2024).


• Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces.: This article reports the development of drug-loaded PLGA microparticles designed to prevent biofilm formation on oral surfaces, demonstrating the polymer′s utility in dental applications and biofilm-associated infections (Oh et al., 2024).


• Dual-layer conduit containing VEGF-A - Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis.: PLGA-based dual-layer conduits are utilized to support nerve regeneration by enhancing angiogenesis, indicating its importance in neuroregenerative medicine and peripheral nerve injury treatments (Huang et al., 2024).


• Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.: The study highlights the dual-targeting capability of PLGA nanoparticles in delivering chemotherapy drugs to both tumor cells and the surrounding supportive stroma, emphasizing its role in advanced cancer therapies (He et al., 2024).

특징 및 장점

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

물리적 형태

Biocompatible, biodegradable polymer.

법적 정보

Lactel is a registered trademark of Evonik Corp

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)