추천 제품
설명
25-hydroxycholesterol-3-sulfate (sodium salt)
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 10 mg (700017P-10mg)
pkg of 1 × 5 mg (700017P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+]
일반 설명
25-hydroxycholesterol-3-sulfate (25OHC3S) is a nuclear oxysterol. It accumulates in hepatocyte nuclei upon steroidogenic acute regulatory protein (STARD1) overexpression.
애플리케이션
25-hydroxycholesterol-3-sulfate has been used to induce anti-inflammatory responses and understand its effect on lymphocyte migration. It has also been used as an oxysterol sulfate standard in mass spectroscopy and liquid chromatography methods.
생화학적/생리학적 작용
25-hydroxycholesterol-3-sulfate (25OHC3S) is involved in lipid homeostasis in liver and is a lipid metabolism regulator. 25OHC3S acts on liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) and inhibits cholesterol synthesis by downregulating enzymes of the biosynthesis pathway in hepatocytes and macrophages. It also acts an agonist for peroxisome proliferator-activated receptor γ (PPAR-γ) and modulates the nuclear factor κ-light-chain-enhancer (NF-κB) based inflammatory response. 25OHC3S modulates tumor necrosis factor α (TNFα)-induced inflammatory response in hepatocytes.
포장
5 mL Amber Glass Screw Cap Vial (700017P-10mg)
5 mL Amber Glass Screw Cap Vial (700017P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Shunlin Ren et al.
Biochemical and biophysical research communications, 360(4), 802-808 (2007-07-13)
Recently, a novel oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate (25HC3S) was identified in primary rat hepatocytes following overexpression of the cholesterol transport protein, StarD1. This oxysterol was also detected in human liver nuclei. In the present study, 25HC3S was chemically synthesized. Addition
Leyuan Xu et al.
American journal of physiology. Endocrinology and metabolism, 302(7), E788-E799 (2012-01-26)
The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are important in regulating lipid metabolism and inflammatory responses in macrophages. Activation of PPARγ represses key inflammatory response gene expressions. Recently, we identified a new cholesterol metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), as a potent regulatory
Yongjie Ma et al.
American journal of physiology. Endocrinology and metabolism, 295(6), E1369-E1379 (2008-10-16)
The oxysterol receptor LXR is a key transcriptional regulator of lipid metabolism. LXR increases expression of SREBP-1, which in turn regulates at least 32 genes involved in lipid synthesis and transport. We recently identified 25-hydroxycholesterol-3-sulfate (25HC3S) as an important regulatory
Leyuan Xu et al.
Lipids, 45(9), 821-832 (2010-08-12)
Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes. The
Tetsuya Sakurai et al.
Science signaling, 11(541) (2018-08-02)
Although immune responses are essential to protect the body from infection, they can also harm tissues. Certain tissues and organs, including the eye, constitute specialized microenvironments that locally inhibit immune reactivity. Dedicator of cytokinesis protein 2 (DOCK2) is a Rac-specific
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