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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C45H70D6O2
CAS 번호:
Molecular Weight:
655.12
MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.12
제품 이름
desmosterol (D6) ester, 26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution
분석
>99% (TLC)
양식
methylene chloride solution
포장
pkg of 1 × 1 mL (700184M-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 700184M
농도
1 mg/mL (700184M-1mg)
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
생화학적/생리학적 작용
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
포장
5 mL Clear Glass Sealed Ampule (700184M-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Central nervous system
WGK
WGK 2
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Phillip A Wages et al.
Journal of lipid research, 59(10), 1916-1926 (2018-08-09)
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases. One sterol precursor, desmosterol (Des), is a potential pharmacological target for inflammatory and
Maurice Jansen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(3), 865-870 (2012-12-12)
The brain is the most cholesterol-enriched tissue in the body. During brain development, desmosterol, an immediate precursor of cholesterol, transiently accumulates up to 30% of total brain sterols. This massive desmosterol deposition appears to be present in all mammalian species
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