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Merck
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주요 문서

810211C

Avanti

C12-NBD Ceramide

Avanti Research™ - A Croda Brand 810211C

동의어(들):

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C36H61N5O6
CAS Number:
202850-01-9
Molecular Weight:
659.90
MDL number:
MFCD02259239
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

양식

liquid

포장

pkg of 1 × 1 mL (810211C-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand 810211C

농도

1 mg/mL (810211C-1mg)

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO

InChI

1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1

InChI key

SNOJCYCOPNIGIK-ULETYAGTSA-N

애플리케이션

C12-NBD ceramide is suitable for its use:
  • as a substrate to measure the activity of acid, alkaline and neutral ceramidases
  • in in vitro ceramidase activity assay
  • in ceramide phosphoethanolamine (CPE) synthase assay to determine the Km and Vmax of sphingomyelin synthase (SMS1, SMS2, and SMSr)

생화학적/생리학적 작용

Ceramide is one of the products of sphingolipid metabolism. The members of ceramide synthase family are responsible for its synthesis. Each ceramide synthesized differs in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

포장

5 mL Amber Glass Screw Cap Vial (810211C-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H302,H315,H319,H331,H336,H351,H361d,H372

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

표적 기관

Central nervous system

WGK

WGK 3

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis I. ALTERATIONS IN LIPID METABOLIC PATHWAYS
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The Journal of Biological Chemistry, 285(14), 10902-10910 (2010)
The ATP-binding cassette transporter-2 (ABCA2) overexpression modulates sphingosine levels and transcription of the amyloid precursor protein (APP) gene
Davis W
Current Alzheimer Research, 12(9), 847-859 (2015)
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity
Ding T, et al.
Journal of Lipid Research, 56(3), 537-545 (2015)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)
Li-Yu Chen et al.
Nature communications, 6, 6030-6030 (2015-01-17)
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