857371P
Avanti
VU0359595
(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder
동의어(들):
EVJ; VU0359595
로그인조직 및 계약 가격 보기
모든 사진(4)
About This Item
실험식(Hill 표기법):
C25H29BrN4O2
CAS Number:
Molecular Weight:
497.43
UNSPSC 코드:
12352211
NACRES:
NA.25
추천 제품
![VU0285655-1 N-{2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-8-yl]ethyl}quinoline-3-carboxamide, powder](/deepweb/assets/sigmaaldrich/product/structures/178/298/7a6fe33b-77ca-4e7d-b30f-2229649668d7/640/7a6fe33b-77ca-4e7d-b30f-2229649668d7.png)
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 1 mg (857371P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 857371P
지질 유형
bioactive lipids
배송 상태
dry ice
저장 온도
−20°C
일반 설명
VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder
애플리케이션
VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout mice to study its effects on them.
생화학적/생리학적 작용
VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.
포장
5 mL Amber Glass Screw Cap Vial (857371P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas
Mathews TP, et al.
ACS Chemical Biology, 10(5), 1258-1268 (2015)
The role of phospholipase D in regulated exocytosis
Rogasevskaia TP and Coorssen JR
The Journal of biological chemistry, 290(48), 28683-28696 (2015)
Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells
Wang Z, et al.
Developmental Cell, 43(2), 186-197 (2017)
Jana A Lewis et al.
Bioorganic & medicinal chemistry letters, 19(7), 1916-1920 (2009-03-10)
This Letter describes the synthesis and structure-activity-relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of alternative halogenated piperidinyl benzimidazolone privileged structures, in combination with a key (S)-methyl group, novel PLD inhibitors with low nM potency and unprecedented
Xianping Li et al.
Infection and immunity, 80(1), 429-440 (2011-11-16)
Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. However, knowledge of the impact
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