A-083

Amiodarone-D₄ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 실험식(Hill 표기법): C₂₅D₄H₂₆ClI₂NO₃
• CAS Number: 1216715-80-8
• Molecular Weight: 685.80
• EC Number: 200-659-6
• MDL number: MFCD08064189
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329770634
• NACRES: NA.24

속성

• Grade: certified reference material
• 형태: liquid
• 특징: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 100 μg/mL in methanol (as free base)
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: clinical testing
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: Cl.[2H]C([2H])(Oc1c(I)cc(cc1I)C(=O)c2c(CCCC)oc3ccccc23)C([2H])([2H])N(CC)CC
• InChI: 1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H/i13D2,14D2;
• InChI key: ITPDYQOUSLNIHG-MMJSDMDPSA-N

설명

일반 설명

A Certified Spiking Solution^®and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone^®, Cordarone^®, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

애플리케이션

• UV-Triggered Drug Release from Nanoparticles: Research explores the enhanced antibacterial activity of berberine hydrochloride-loaded mesoporous titanium nanoparticles, activated by UV exposure, providing insights into novel drug delivery systems for antiarrhythmic drugs like Amiodarone-D₄ hydrochloride in medical treatments (Zuo et al., 2024).


• Antioxidant Activity and Eczema Treatment: A study evaluates the antioxidant properties and therapeutic effects of berberine hydrochloride-loaded liposomes in gel form, potentially analogous to applications for encapsulated forms of Amiodarone-D₄ in dermal pharmaceutical preparations (Shen et al., 2024).


• Synthetic Routes for Cancer Therapy: A review on the synthetic pathways and clinical applications of small-molecule EGFR inhibitors for cancer treatment provides a framework that can be applied to the development and application of Amiodarone-D₄ hydrochloride in oncological research (Wang et al., 2024).


• Drug Release Behaviors in Nanoparticles: Investigation into the impact of various factors on the properties of poly(lactic-co-glycolic acid) nanoparticles co-loaded with hydrophilic and hydrophobic drugs, relevant for the formulation of Amiodarone-D₄ hydrochloride for controlled drug delivery systems (Wang et al., 2024).


• Traditional Chinese Medicine and Sjögren Syndrome: Case report on a rare pattern of primary Sjögren syndrome treated with traditional Chinese medicine, highlighting the diverse therapeutic approaches that could integrate Amiodarone-D₄ hydrochloride in complex treatment regimens (Chen et al., 2024).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Cordarone is a registered trademark of Sanofi S.A.

Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup