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Merck
모든 사진(1)

Key Documents

H-110

Supelco

Hydroxyitraconazole

100 μg/mL in methanol, certified reference material, Cerilliant®

로그인조직 및 계약 가격 보기


About This Item

실험식(Hill 표기법):
C35H38Cl2N8O5
CAS Number:
Molecular Weight:
721.63
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

certified reference material

Quality Level

형태

liquid

특징

Snap-N-Spike®/Snap-N-Shoot®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

농도

100 μg/mL in methanol

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

clinical testing

형식

single component solution

저장 온도

−20°C

InChI

1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3

InChI key

ISJVOEOJQLKSJU-UHFFFAOYSA-N

일반 설명

Hydroxyitraconazole is an active metabolite of itraconazole, an antifungal drug used for the treatment of fungal infections. Therapeutic drug monitoring of hydroxyitraconazole is utilized in the management of patients receiving itraconazole to ensure therapeutic levels of the drug have been achieved. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of hydroxyitraconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

애플리케이션


  • Hydroxyitraconazole Antifungal Research: Utilized prominently in antifungal research, Hydroxyitraconazole serves as a potent inhibitor in studies targeting resistant fungal strains, contributing significantly to the development of more effective antifungal therapies (Krug et al., 2023).

  • Itraconazole Metabolite Study: As a major metabolite of itraconazole, Hydroxyitraconazole is crucial in pharmacokinetic studies to understand the metabolism of itraconazole, aiding in optimizing dosing for better therapeutic outcomes (Miljković et al., 2022).

  • Pharmaceutical Research Chemicals: This compound is pivotal in pharmaceutical research, providing insights into the drug′s behavior in biological systems and its interaction with other pharmacological agents, thereby facilitating drug development and safety evaluations (Iwasaki et al., 2019).

  • Antifungal Drug Discovery: Integral to antifungal drug discovery, Hydroxyitraconazole aids in screening and developing new drug candidates, especially those targeting difficult-to-treat infections, thus expanding the arsenal against global fungal threats (Müller et al., 2017).



법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

관련 제품

제품 번호
설명
가격

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup


시험 성적서(COA)

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