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Merck
모든 사진(1)

Key Documents

05-776

Sigma-Aldrich

Anti-ZAP-70 Antibody, clone 1E7.2

clone 1E7.2, Upstate®, from mouse

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모든 사진(1)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

100

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

1E7.2, monoclonal

종 반응성

human, mouse

제조업체/상표

Upstate®

기술

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG1

NCBI 수납 번호

NM_001079

UniProt 수납 번호

P43403

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

mouse ... Ppp1Ca(19045)

일반 설명

Note: This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California

특이성

Zap-70

면역원

GST fusion protein between the second SH2 domain and precedes the kinase domain corresponding to residues 282-307 of human ZAP-70

애플리케이션

Anti-ZAP-70 Antibody, clone 1E7.2 is an antibody against ZAP-70 for use in IC, IP & WB.
Research Category
Signaling
Research Sub Category
Immunological Signaling

품질

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

표적 설명

Mr ~70kDa

물리적 형태

Format: Purified
Protein G Purified
of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

저장 및 안정성

2 years at -20°C

분석 메모

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

기타 정보

Due to license agreement restrictions, this product cannot be purchased for resale.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Kristin Hochweller et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5931-5936 (2010-03-17)
Dendritic cells (DCs) are key components of the adaptive immune system contributing to initiation and regulation of T cell responses. T cells continuously scan DCs in lymphoid organs for the presence of foreign antigen. However, little is known about the
Lin Shen et al.
Science signaling, 14(668) (2021-02-04)
The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early-onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P mutation are consistent with
TCR signaling: another Abl-bodied kinase joins the cascade.
Wange, Ronald L
Current Biology, 14, R562-R564 (2004)
Masaki Matsumoto et al.
Proteomics, 9(13), 3549-3563 (2009-07-18)
Activation of the T-cell receptor (TCR) and that of the B-cell receptor (BCR) elicits tyrosine-phosphorylation of proteins that belongs to similar functional categories, but result in distinct cellular responses. Large-scale analyses providing an overview of the signaling pathways downstream of
Yu Mi Oh et al.
Nature communications, 6, 8698-8698 (2015-10-29)
Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not fully understood yet. Here we identify Ndrg1 as an anergy factor induced by Egr2. Ndrg1

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