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Merck
모든 사진(3)

Key Documents

07-641

Sigma-Aldrich

Anti-MEK1 Antibody

Upstate®, from rabbit

동의어(들):

Anti-CFC3, Anti-MAPKK1, Anti-MEK1, Anti-MEL, Anti-MKK1, Anti-PRKMK1

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모든 사진(3)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

100

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성

mouse, rat, human

제조업체/상표

Upstate®

기술

immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG

NCBI 수납 번호

NM_002755

UniProt 수납 번호

Q02750

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAP2K1(5604)

특이성

MEK1
Predicted to cross-react with rabbit based on sequence homology.

면역원

Peptide corresponding to amino acids 2-18 (PKKKPTPIQLNPAPDGS) of human MEK1.

애플리케이션

Research Category
Signaling
Research Sub Category
MAP Kinases
This Anti-MEK1 Antibody is validated for use in IP, WB for the detection of MEK1.

품질

Routinely evaluated by immunoblot on RIPA lysates from A431 and 3T3/A31 cells.

표적 설명

45kDa

결합

Replaces: 04-376

물리적 형태

70% storage buffer (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol.
Format: Purified
Protein A purified

저장 및 안정성

2 years at -20°C

분석 메모

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for mingels.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

시험 성적서(COA)

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문서 라이브러리 방문

Brian J Girard et al.
The Journal of biological chemistry, 292(1), 339-350 (2016-11-25)
Cytoplasmic localization of proline, glutamic acid, leucine-rich protein 1 (PELP1) is observed in ∼40% of women with invasive breast cancer. In mouse models, PELP1 overexpression in the mammary gland leads to premalignant lesions and eventually mammary tumors. In preliminary clinical
Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.
Teague, M A, et al.
Proceedings of the National Academy of Sciences of the USA, 83, 7371-7375 (1986)
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
Kosako, H, et al.
The Embo Journal, 12, 787-794 (1993)
Jason M Warfel et al.
Toxins, 3(10), 1278-1293 (2011-11-10)
Systemic anthrax disease is characterized by vascular leakage pathologies. We previously reported that anthrax lethal toxin (LT) induces human endothelial barrier dysfunction in a cell death-independent manner with actin stress fiber formation and disruption of adherens junctions (AJs). In the
Felice D'Agnillo et al.
PloS one, 8(4), e62576-e62576 (2013-04-30)
Vascular leakage pathologies such as pleural effusion and hemorrhage are hallmarks of anthrax pathogenesis. We previously reported that anthrax lethal toxin (LT), the major virulence factor of anthrax, reduces barrier function in cultured primary human microvascular endothelial cells. Here, we
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