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Merck
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주요 문서

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203701

Sigma-Aldrich

bpV(HOpic)

A potent phosphotyrosine phosphatase inhibitor.

동의어(들):

bpV(HOpic), Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV

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모든 사진(1)

About This Item

Linear Formula:
K2[VO(O2)2C6H4NO3] · 4H2O
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥70% (51V-NMR)

형태

solid

효능

14 nM IC50

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

yellow

solubility

water: 4 mg/mL

배송 상태

ambient

저장 온도

−20°C

일반 설명

A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).

생화학적/생리학적 작용

Cell permeable: no
Primary Target
PTEN
Product does not compete with ATP.
Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Unstable in solution; reconstitute just prior to use.

기타 정보

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Zeinab Ghezelayagh et al.
Journal of assisted reproduction and genetics, 39(8), 1739-1747 (2022-07-13)
The effect of PTEN inhibitor (Bpv(HOpic); Bpv) and mTOR activators (phosphatidic acid (PA) and propranolol (PP)), were evaluated on the activation and subsequent development of human primordial follicles in ovarian tissue culture. Slow frozen-thawed human ovarian cortical strips were incubated
Amit Kumar et al.
Molecular and cellular biology, 44(7), 261-272 (2024-06-03)
The protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1) plays an important role in modulating glucose and lipid homeostasis. We previously suggested a potential role of SHP-1 in the regulation of peroxisome proliferator-activated receptor γ2 (PPARγ2) expression and
Cyrine Ben Dhaou et al.
Angiogenesis (2021-09-16)
Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here

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