추천 제품
product name
Collagen, Type I, Human Skin,
분석
≥95% (SDS-PAGE)
Quality Level
형태
lyophilized
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
불순물
≤0.1% subdermal hair
solubility
acetic acid: 5 mg/mL (0.5M)
배송 상태
ambient
저장 온도
2-8°C
일반 설명
Collagen type 1 is a fibrillar collagen present abundantly in skin, bone, vasculature, and calcified tissues of teeth and bone. It is also seen in organs like the heart and lungs. Collagen type 1 is a heterotrimer consisting of two α1 (CIα1) and one α2 (CIα2) chains with a helical region made of repeating units of proline and hydroxyproline.
애플리케이션
Collagen Type I, Human Skin has been used as a skin protein to study the effect of age-related NADH oxidase (ar-NOX)-catalyzed oxidation on skin proteins. It has also been used as a control sample in High-resolution mass spectrometry (HRMS) analysis.
생화학적/생리학적 작용
Collagen type 1 is a main component of the dermal extracellular matrix (ECM) and participates in skin elasticity. Mutations in collagen type 1 are associated with osteogenesis imperfecta and Ehlers–Danlos syndrome.
경고
Toxicity: Standard Handling (A)
물리적 형태
Salt-free.
제조 메모
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
재구성
The recommended concentration is 0.01 to 0.5 M Acetic Acid (or another acidic buffer), with a maximum concentration of 5 mg/ml. The product has been tested at 0.5 M Acetic Acid and is stable for 1 month at 2-8°C. After reconstitution, aliquot and freeze at -20°C. Stock solutions remain stable for up to 6 months at this temperature.
기타 정보
Gallop, P.M., and Siefert, S. 1963. Methods Enzymol. 6, 635.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Collagen type I as a ligand for receptor-mediated signaling
Frontiers in physics, 5, 12-12 (2017)
structure, function, and biomarkers
Biochemistry of Collagens, Laminins and Elastin (2019)
Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin.
R Gref et al.
Scientific reports, 10(1), 16883-16883 (2020-10-11)
Vitamin C (Vit C) benefits to human skin physiology notably by stimulating the biosynthesis of collagen. The main cutaneous collagens are types I and III, which are less synthesized with aging. Vit C is one of the main promotors of
Xing Xu et al.
BMC biotechnology, 11, 69-69 (2011-06-28)
Collagens require the hydroxylation of proline (Pro) residues in their triple-helical domain repeating sequence Xaa-Pro-Gly to function properly as a main structural component of the extracellular matrix in animals at physiologically relevant conditions. The regioselective proline hydroxylation is catalyzed by
Christiaan Meadows et al.
Archives of dermatological research, 306(7), 645-652 (2014-06-08)
Age-related NADH oxidase (arNOX), a cell surface-located hydroquinone oxidase capable of superoxide generation, appears at age 30 and increases with age thereafter. The ectodomain of arNOX is shed from the cell surface into body fluids including sera and saliva where
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