264155
Caspase-3 Inhibitor II
The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
동의어(들):
Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C30H41FN4O12
CAS Number:
Molecular Weight:
668.66
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥90% (TLC)
형태
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated
색상
white to slightly brown
solubility
DMSO: 5 mg/mL
배송 상태
ambient
저장 온도
−20°C
InChI
1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChI key
GBJVAVGBSGRRKN-JYEBCORGSA-N
일반 설명
A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Product does not compete with ATP.
Reversible: no
경고
Toxicity: Standard Handling (A)
서열
Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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