317700

Dkk-1 Inhibitor, WAY-262611, HCl

The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

• 동의어(들): Dkk-1 Inhibitor, WAY-262611, HCl, (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
• 실험식(Hill 표기법): C₂₀H₂₂N₄ · xHCl
• Molecular Weight: 318.42 (free base basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC₅₀ = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Pelletier, J.C., et al. 2009. J. Med. Chem.52, 6962.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable