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Merck
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주요 문서

324895

Sigma-Aldrich

eIF-2α Inhibitor, Salubrinal

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.

동의어(들):

eIF-2α Inhibitor, Salubrinal, Sal

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C21H17Cl3N4OS
CAS Number:
304475-63-6
Molecular Weight:
479.81
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥90% (HPLC)

형태

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

beige

solubility

DMSO: 10 mg/mL

배송 상태

wet ice

저장 온도

−20°C

일반 설명

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380)). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.

생화학적/생리학적 작용

Cell permeable: yes
Primary Target
elF-2α
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM preventing HSV replication both in Vero cells.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Boyce, M., et al. 2005. Science307, 935.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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